Principal Investigator
Brazilian Biosciences National Laboratory – LNBio-CNPEM
Campinas,Brazil
http://lnbio.cnpem.br/moraes/
Carolina Borsoi Moraes obtained a PhD in 2009 on Microbiology and Immunology from a joint program between the Institut Pasteur Korea and the Federal University of São Paulo. From 2010 to 2012 she had a postdoctoral position at the Center for Neglected Diseases Drug Discovery (CND3) in Institut Pasteur Korea, coordinating the HCS activities (assay development for lead optimization) for Chagas disease drug discovery.
The research of Dr. Moraes’ group focuses on drug discovery for Chagas disease, using high content screening (HCS) assays that permit the triage of chemical compounds for determination of activity against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease. These assays are amenable to automation and have been used in high throughput mode to screen chemical libraries. Additionally, these assays are used to provide routine testing and guide hit prioritization and chemical optimization of hit compounds selectivity/antiparasitic properties during structure-activity relationship (SAR) studies, a process also known as lead optimization. A major goal is developing and improving in vitro and in vivo assays that will translate human disease into experimental models applicable to drug discovery programs, ultimately leading to the discovery of novel chemotherapeutic agents for Chagas disease, while generating knowledge about Chagas disease pathogenesis.
