{"id":145,"date":"2014-08-11T17:06:36","date_gmt":"2014-08-11T20:06:36","guid":{"rendered":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/?page_id=145"},"modified":"2014-08-11T17:07:35","modified_gmt":"2014-08-11T20:07:35","slug":"integrative-approaches-in-toxinology-perspectives-and-implications-of-omics-methodologies-in-the-study-of-snake-venom-toxins","status":"publish","type":"page","link":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/integrative-approaches-in-toxinology-perspectives-and-implications-of-omics-methodologies-in-the-study-of-snake-venom-toxins\/","title":{"rendered":"Integrative approaches in toxinology: perspectives and implications of \u2018omics\u2019 methodologies in the study of snake venom toxins"},"content":{"rendered":"

 <\/p>\n

Andr\u00e9 Zelanis<\/span><\/a><\/span>1,2<\/sup><\/p>\n

1Departamento de Ci\u00eancia e Tecnologia, Universidade Federal de S\u00e3o Paulo, campus de S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo, Brazil (present address)<\/p>\n

2<\/sup> Laborat\u00f3rio Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, S\u00e3o Paulo, Brazil<\/p>\n

The study of snake venom proteomes (venomics) has been experiencing a burst of reports, however the comprehensive knowledge of the dynamic range of proteins present within a single venom, the set of post-translational modifications (PTMs) as well as the lack of a comprehensive database related to venom proteins are among the main challenges in venomics research. The phenotypic plasticity in snake venom proteomes together with their inherent toxin proteoform diversity, points out to the use integrative analysis in order to better understand their actual complexity. In this regard, such a systems venomics task should encompass the integration of data from transcriptomic and proteomic studies (specially the venom gland proteome), the identification of biological PTMs, and the estimation of artifactual proteomes and peptidomes generated by sample handling procedures. The recent recognition of snake envenoming as a neglected tropical disease denotes the significance of systemic studies in toxinology. Thus, the knowledge of structural and functional snake venom proteomes can serve as basis for anti-venom improvement, one of the main challenges in developing countries.<\/p>\n","protected":false},"excerpt":{"rendered":"

  Andr\u00e9 Zelanis1,2 1Departamento de Ci\u00eancia e Tecnologia, Universidade Federal de S\u00e3o Paulo, campus de S\u00e3o Jos\u00e9 dos Campos, S\u00e3o Paulo, Brazil (present address) 2 Laborat\u00f3rio Especial de Toxinologia Aplicada, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, S\u00e3o Paulo, Brazil The study of snake venom proteomes (venomics) has been experiencing a burst…<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-145","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/wp-json\/wp\/v2\/pages\/145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/wp-json\/wp\/v2\/comments?post=145"}],"version-history":[{"count":0,"href":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/wp-json\/wp\/v2\/pages\/145\/revisions"}],"wp:attachment":[{"href":"http:\/\/pages.cnpem.br\/proteomicsworkshop\/wp-json\/wp\/v2\/media?parent=145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}