{"id":20,"date":"2025-02-18T18:43:16","date_gmt":"2025-02-18T18:43:16","guid":{"rendered":"https:\/\/pages.cnpem.br\/isbdd\/?page_id=20"},"modified":"2025-05-20T21:03:38","modified_gmt":"2025-05-20T21:03:38","slug":"program","status":"publish","type":"page","link":"https:\/\/pages.cnpem.br\/isbdd\/program\/","title":{"rendered":"PROGRAM"},"content":{"rendered":"

[vc_row][vc_column][vc_custom_heading text=”Integrative Structural Biology meets Drug Discovery
\nWorkshop for Early Career Scientists
\n19-23 May 2025, CNPEM, Campinas, Brazil” font_container=”tag:h2|font_size:24|text_align:left” google_fonts=”font_family:Chivo%3Aregular%2Citalic%2C900%2C900italic|font_style:400%20regular%3A400%3Anormal” css=””][vc_tta_accordion style=”flat” shape=”square” color=”black” gap=”2″ active_section=”1″ no_fill=”true” collapsible_all=”true”][vc_tta_section title=”Monday\/Day 1 – 19 May 2025″ tab_id=”1739903804172-0b430b85-2dca”][vc_column_text css=””]<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Start<\/strong><\/td>\nEnd<\/strong><\/td>\nTalk title<\/strong><\/td>\n<\/tr>\n
8:00<\/td>\n8:30<\/td>\nArrival<\/td>\n<\/tr>\n
8:30<\/td>\n9:00<\/td>\nWelcome & Aim of the workshop<\/p>\n

Daniela Trivella and Rodrigo Portugal, CNPEM
\n<\/em><\/td>\n<\/tr>\n

9:00<\/td>\n9:30<\/td>\nShort presentation of workshop organisers\/training team (5-7min) Daniela<\/em> Trivella, CNPEM
\nKarina Alleva, CEBEM
\n<\/span><\/em>Bahne Stechmann, EU-OPENSCREEN
\n<\/em>Rodrigo Portugal, CNPEM
\n<\/em>John Dolan, Instruct-ERIC<\/em><\/td>\n<\/tr>\n
9:30<\/td>\n10:00<\/td>\nIntroduction of participants<\/td>\n<\/tr>\n
10:00<\/td>\n10:30<\/td>\nCoffee break (30\u2019)<\/em><\/td>\n<\/tr>\n
10:30<\/strong><\/td>\n11:30<\/strong><\/td>\nSession on Drug Discovery\u00a0<\/em><\/strong><\/td>\n<\/tr>\n
10:30<\/td>\n11:00<\/td>\nOverview of Drug Discovery & Development<\/p>\n

Daniela Trivella, CNPEM\u00a0<\/em><\/td>\n<\/tr>\n

11:00<\/td>\n11:30<\/td>\nDrug Discovery process & strategies<\/p>\n

Rui Moreira, iMed University of Lisbon\u00a0<\/em><\/td>\n<\/tr>\n

11:30<\/strong><\/td>\n12:30<\/strong><\/td>\nSession on Drug Discovery\u00a0<\/em><\/strong><\/td>\n<\/tr>\n
11:30<\/td>\n12:00<\/td>\nTarget selection and validation<\/p>\n

Katlin Massirer, CQMED UNICAMP\u00a0<\/em><\/td>\n<\/tr>\n

12:00<\/td>\n12:30<\/td>\nHit discovery options: Target-based (biochemical, biophysical, fragment screening) and phenotypic screening methods<\/p>\n

Olga Genilloud, Fundaci\u00f3n MEDINA\u00a0<\/em><\/td>\n<\/tr>\n

12:30<\/td>\n13:00<\/td>\nQ&A session<\/td>\n<\/tr>\n
13:00<\/td>\n14:00<\/td>\nLunch (60\u2019)<\/em><\/td>\n<\/tr>\n
14:00<\/strong><\/td>\n15:30<\/strong><\/td>\nSession on Drug Discovery\u00a0<\/em><\/strong><\/td>\n<\/tr>\n
14:00<\/td>\n14:30<\/td>\nAssay development and quality control<\/p>\n

Bahne Stechmann, EU-OPENSCREEN<\/em><\/td>\n<\/tr>\n

14:30<\/td>\n15:00<\/td>\nIn silico<\/em> approaches to Drug Discovery<\/p>\n

Floriano Silva, Fiocruz\u00a0<\/em><\/td>\n<\/tr>\n

15:00<\/td>\n15:30<\/td>\nStructural biology in Drug Discovery<\/p>\n

Lizbe Koekemoer, Centre for Medicines Discovery (CMD), University of Oxford<\/span><\/td>\n<\/tr>\n

15:30<\/td>\n16:00<\/td>\nCoffee break (30\u2019)<\/em><\/td>\n<\/tr>\n
16:00<\/strong><\/td>\n17:30<\/strong><\/td>\nSession on Structural Biology\u00a0<\/em><\/strong><\/td>\n<\/tr>\n
16:00<\/td>\n16:30<\/td>\nIntroduction to X-ray crystallography<\/p>\n

Beatriz Guimar\u00e3es,<\/em> FIOCRUZ Paran\u00e1<\/em><\/td>\n<\/tr>\n

16:30<\/td>\n17:00<\/td>\nIntroduction to NMR (remote)<\/p>\n

Enrico Rivera, <\/span>CIRMMP University of Florence<\/span><\/em><\/td>\n<\/tr>\n

17:00<\/td>\n17:30<\/td>\nIntroduction to cryo-EM<\/p>\n

Jos\u00e9 Maria Valpuesta, CNB-CSIC<\/span><\/td>\n<\/tr>\n

17:30<\/td>\n18:30<\/td>\nNetworking & Social gathering<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Tuesday\/Day 2 – 20 May 2025″ tab_id=”1739903804188-9128b763-01d9″][vc_column_text css=””]<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Start<\/strong><\/td>\nEnd<\/strong><\/td>\nTalk title<\/strong><\/td>\n<\/tr>\n
8:00<\/td>\n8:30<\/td>\nTransfer to venue<\/em><\/td>\n<\/tr>\n
8:30<\/strong><\/td>\n10:00<\/strong><\/td>\nSession on Chemical Libraries<\/em><\/strong><\/td>\n<\/tr>\n
8:30<\/td>\n9:00<\/td>\nChemical libraries, annotation & compound management<\/p>\n

Rui Moreira, iMed University of Lisbon\u00a0<\/em><\/td>\n<\/tr>\n

9:00<\/td>\n9:30<\/td>\nNatural products in the 21th century<\/p>\n

Olga Genilloud, Fundaci\u00f3n MEDINA<\/em><\/td>\n<\/tr>\n

9:30<\/td>\n10:00<\/td>\nChemical probes, fragment libraries and new drug modalities<\/p>\n

Rui Moreira, iMed University of Lisbon<\/em><\/td>\n<\/tr>\n

10:00<\/td>\n10:30<\/td>\nCoffee break (30\u2019)<\/em><\/td>\n<\/tr>\n
10:00<\/strong><\/td>\n11:30<\/strong><\/td>\nSession on Screening and bioassays<\/em><\/strong><\/td>\n<\/tr>\n
10:30<\/td>\n11:00<\/td>\nBiochemical and biophysical assays<\/p>\n

Daniela Trivella, CNPEM<\/em><\/td>\n<\/tr>\n

11:00<\/td>\n11:30<\/td>\nPhenotypic assays and complex cell models<\/p>\n

Olga Genilloud, Fundaci\u00f3n MEDINA<\/em><\/td>\n<\/tr>\n

11:30<\/strong><\/td>\n13:00<\/strong><\/td>\nSession on hit follow up<\/em><\/strong><\/td>\n<\/tr>\n
11:30<\/td>\n12:00<\/td>\nHit-to-lead optimisation principles (importance of ADME-Tox in DD)<\/p>\n

Marjorie Bruder, CNPEM<\/em><\/td>\n<\/tr>\n

12:00<\/td>\n12:30<\/td>\nIntroduction to lead optimization (compound optimization by chemical synthesis)<\/p>\n

Marjorie Bruder, CNPEM<\/span><\/td>\n<\/tr>\n

12:30<\/td>\n13:00<\/td>\nQ&A session<\/td>\n<\/tr>\n
13:00<\/td>\n14:00<\/td>\nLunch (60\u2019)<\/em><\/td>\n<\/tr>\n
14:00<\/strong><\/td>\n15:30<\/strong><\/td>\nSession on NMR<\/em><\/strong><\/td>\n<\/tr>\n
14:00<\/td>\n14:30<\/td>\nNMR <\/em>\u2013 principles part I<\/p>\n

Luzineide Tinoco, Federal University of Rio de Janeiro<\/em><\/td>\n<\/tr>\n

14:30<\/td>\n15:00<\/td>\nNMR <\/em>\u2013 principles part II<\/p>\n

Luzineide Tinoco, Federal University of Rio de Janeiro<\/span><\/td>\n<\/tr>\n

15:00<\/td>\n15:30<\/td>\nNMR <\/em>\u2013 fragment screening<\/p>\n

Luzineide Tinoco, Federal University of Rio de Janeiro<\/em><\/td>\n<\/tr>\n

15:30<\/td>\n16:00<\/td>\nCoffee break (30\u2019)\u00a0<\/em><\/td>\n<\/tr>\n
16:00<\/td>\n18:00<\/td>\nSession on Protein Crystallography<\/em><\/strong><\/td>\n<\/tr>\n
16:00<\/td>\n16:30<\/td>\nProtein Crystallography \u2013 principles part I<\/p>\n

Beatriz Guimar\u00e3es,<\/em> FIOCRUZ Paran\u00e1<\/em><\/td>\n<\/tr>\n

16:30<\/td>\n17:00<\/td>\nProtein Crystallography \u2013 principles part II<\/p>\n

Andr\u00e9 Ambr\u00f3sio University of S\u00e3o Paulo<\/span><\/td>\n<\/tr>\n

17:00<\/td>\n17:30<\/td>\nProtein Crystallography \u2013 fragment screening<\/p>\n

Lizbe Koekemoer, Centre for Medicines Discovery (CMD), University of Oxford<\/span><\/td>\n<\/tr>\n

17:30<\/td>\n18:00<\/td>\nProtein Crystallography \u2013 Case study: Manaca beamline Sirius-CNPEM<\/p>\n

Andrey Nascimento, CNPEM<\/em><\/td>\n<\/tr>\n

18:00<\/td>\n19:00<\/td>\nTransport to hotel<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Wednesday\/Day 3 – 21 May 2025″ tab_id=”1739904135833-61991e54-1701″][vc_column_text css=””]<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Start<\/strong><\/td>\nEnd<\/strong><\/td>\nTalk title<\/strong><\/td>\n<\/tr>\n
8:00<\/td>\n8:30<\/td>\nTransfer to venue<\/em><\/td>\n<\/tr>\n
8:30<\/strong><\/td>\n10:00<\/strong><\/td>\nSession on cryo-EM<\/em><\/strong><\/td>\n<\/tr>\n
8:30<\/td>\n9:00<\/td>\n\n
CryoEM \u2013 Principles of Data Processing<\/div>\n
Rodrigo Portugal, CNPEM<\/em><\/div>\n<\/td>\n<\/tr>\n
9:00<\/td>\n9:30<\/td>\n\n
CryoEM \u2013 Current challenges for cryo-EM at an industrial scale<\/div>\n
Michael Saur, Astex<\/em><\/div>\n<\/td>\n<\/tr>\n
9:30<\/td>\n10:00<\/td>\n\n
CryoEM –\u00a0<\/span>Combining Structural and Functional Data: The Many Controls of the Enzyme Tyrosine Hydroxylase<\/div>\n
Jos\u00e9 Maria Valpuesta, CNB-CSIC<\/em><\/div>\n<\/td>\n<\/tr>\n
10:00<\/td>\n10:30<\/td>\nCoffee break (30\u2019)<\/em><\/td>\n<\/tr>\n
10:30<\/strong><\/td>\n13:00<\/strong><\/td>\nSession on integrative approaches<\/span><\/td>\n<\/tr>\n
10:30<\/td>\n12:00<\/td>\n\n
Accelerating biological research using AlphaFold 3\u00a0(remote)<\/div>\n
Oleg Kovalevskiy, DeepMind<\/em><\/div>\n<\/td>\n<\/tr>\n
12:00<\/td>\n12:30<\/td>\nHelder Veras, CNPEM<\/em><\/td>\n<\/tr>\n
12:30<\/td>\n13:00<\/td>\nIntegrating structural methods to elucidate the activation mechanism of human glutaminases
\nAndre Ambr\u00f3sio, University of S\u00e3o Paulo\u00a0<\/em><\/span><\/td>\n<\/tr>\n
13:00<\/td>\n14:00<\/td>\nLunch (60\u2019)<\/em><\/td>\n<\/tr>\n
14:00<\/td>\n14:45<\/td>\n\n
Cryo-EM for FBDD\/SBDD at Astex<\/span><\/div>\n
Michael Saur, Astex<\/em><\/div>\n<\/td>\n<\/tr>\n
14:45<\/td>\n15:00<\/td>\nClosing (theoretical part)<\/em><\/td>\n<\/tr>\n
15:00<\/td>\n18:00<\/td>\nVisit to CNPEM facilities<\/strong><\/td>\n<\/tr>\n
18:00<\/td>\n19:00<\/td>\nTransport to hotel<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Thursday\/Day 4 – 22 May 2025″ tab_id=”1739904264135-e529ce73-5563″][vc_column_text css=””]<\/p>\n\n\n\n\n\n\n\n\n\n
Start<\/strong><\/td>\nEnd<\/strong><\/td>\nTalk title<\/strong><\/td>\n<\/tr>\n
8:00<\/td>\n8:30<\/td>\nTransfer to venue<\/em><\/td>\n<\/tr>\n
8:30<\/strong><\/td>\n12:30<\/strong><\/td>\nExperimental session #1<\/em><\/strong><\/td>\n<\/tr>\n
12:30<\/td>\n13:30<\/td>\nLunch (60\u2019)<\/em><\/td>\n<\/tr>\n
13:30<\/strong><\/td>\n17:30<\/strong><\/td>\nExperimental session #2<\/em><\/strong><\/td>\n<\/tr>\n
17:30<\/td>\n18:00<\/td>\nQ&A Practical Part<\/td>\n<\/tr>\n
18:00<\/td>\n19:00<\/td>\nTransport to hotel<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/vc_column_text][\/vc_tta_section][vc_tta_section title=”Friday\/Day 5 – 23 May 2025″ tab_id=”1739904314769-32f1b164-0363″][vc_column_text css=””]<\/p>\n\n\n\n\n\n\n\n\n\n
Start<\/strong><\/td>\nEnd<\/strong><\/td>\nTalk title<\/strong><\/td>\n<\/tr>\n
8:00<\/td>\n8:30<\/td>\nTransfer to venue<\/em><\/td>\n<\/tr>\n
8:30<\/strong><\/td>\n12:30<\/strong><\/td>\nExperimental session #3<\/em><\/strong><\/td>\n<\/tr>\n
12:30<\/td>\n13:30<\/td>\nLunch (60\u2019)<\/em><\/td>\n<\/tr>\n
13:30<\/strong><\/td>\n17:30<\/strong><\/td>\nExperimental session #4<\/em><\/strong><\/td>\n<\/tr>\n
17:30<\/td>\n18:00<\/td>\nClosing remarks<\/td>\n<\/tr>\n
18:00<\/td>\n19:00<\/td>\nTransport to hotel<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/vc_column_text][\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_custom_heading text=”Integrative Structural Biology meets Drug Discovery Workshop for Early Career Scientists 19-23 May 2025, CNPEM, Campinas, Brazil” font_container=”tag:h2|font_size:24|text_align:left” google_fonts=”font_family:Chivo%3Aregular%2Citalic%2C900%2C900italic|font_style:400%20regular%3A400%3Anormal” css=””][vc_tta_accordion style=”flat” shape=”square” color=”black” gap=”2″ active_section=”1″ no_fill=”true” collapsible_all=”true”][vc_tta_section title=”Monday\/Day 1 – 19 May 2025″ tab_id=”1739903804172-0b430b85-2dca”][vc_column_text css=””] Start End Talk title 8:00 8:30 Arrival 8:30 9:00 Welcome & Aim of the workshop Daniela Trivella and Rodrigo…<\/p>\n","protected":false},"author":1471,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-20","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/pages.cnpem.br\/isbdd\/wp-json\/wp\/v2\/pages\/20","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pages.cnpem.br\/isbdd\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pages.cnpem.br\/isbdd\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pages.cnpem.br\/isbdd\/wp-json\/wp\/v2\/users\/1471"}],"replies":[{"embeddable":true,"href":"https:\/\/pages.cnpem.br\/isbdd\/wp-json\/wp\/v2\/comments?post=20"}],"version-history":[{"count":0,"href":"https:\/\/pages.cnpem.br\/isbdd\/wp-json\/wp\/v2\/pages\/20\/revisions"}],"wp:attachment":[{"href":"https:\/\/pages.cnpem.br\/isbdd\/wp-json\/wp\/v2\/media?parent=20"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}